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pentobarbital decreases amounts of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers maximize charge of toremifene metabolism, lowering the constant-condition concentration in serum.pentobarbital will minimize the extent or effect of oxybutynin by influencing hepatic/intestinal enzyme CYP3A4 met